A major thrust of our current work is investigating ways to improve the safety, efficiency, and accessibility of therapeutic gene editing. We are studying high throughput methods for efficiently delivering genes and gene editing systems to large numbers of cells outside of the body.
We build microfluidic systems that take advantage of the unique mechanics of complex and viscoelastic fluids, which are relevant to biological specimens and bio-manufacturing advanced therapeutics. We are particularly interested in flow phenomena that emerge in 'extreme' flow regimes of high inertia and elasticity.
We are developing new tools to study the biomechanics of cell membrane rupture, repair, and remodeling, with the goal of discovering better ways to gently deliver molecules and nanoparticles into cells.